Swiss television newscast SF1 reported the high casualty numbers, adding that the incident happened at approximately 7pm local time.
The French RER train service has temporarily halted transportation between the two western municipalities of Moudon and Payerne, between which the crash took place. A replacement bus service has been established. Firefighters, ambulances, helicopters, and police are on site.
The distance between the two areas spans just over 20 kilometers.